Centrioles: The Lazy Organelle

The Sleeping Centrioles

Centrioles are cowards. Yes, they may look like churros. Yes, they are involved in the important processes of cell division during prophase, anaphase and telophase which is when they split chromosomes into two and a new nuclear envelope is formed. But apart from that mumbo jumbo they just relax in interphase and do not contribute to the cell anymore and are a threat to human life. They are truly the lazy organelle and only are located in animal cells, plants are important too, I mean if you like oxygen. C'mon lets be honest, they are not the organelle you want to elect to be Chief Organelle. He would just want to sleep in office and only work for a little bit at the beginning of his term. Not the leader this country needs.

They have been linked to many defects as they are essential in the formation of centrosomes and cilia. A defect in the centrosome is common in the formation in tumors and genome instability. Man, when they give a cell poor cilia it can lead to some pretty big issues with that person. Dysfunctional cilia is linked to diabetes, obesity, loss of vision, cystic kidney disease, mental retardation, polydactyly, and short bones.

Cystic Kidney Disease. Thanks a lot centrioles.

Polydactyly, always lending a hand centrioles.

The centrioles have shown to have some importance to the cell but you decide if all these potential risks are worth it? Do you think this organelle should be put in office? Like really, think about it. Ciliary dysfunctions caused by the centrioles are leading to life threatening diseases. The world is already a dangerous place, do we want to really put someone that causes this many issues in charge. According to the CDC, diabetes is the #7 cause of death in America, which happens to be a ciliary dysfunction. 

Ciliary Dysfunction leads to obesity, an increasing problem in America.

A centriole killer.

Works Cited:

•  Eddé, B; Rossier, J; Le Caer, JP; Desbruyères, E; Gros, F; Denoulet, P (1990). Posttranslational glutamylation of alpha-tubulin. Science 247(4938): 83–5. Bibcode:1990Sci...247...83E.doi:10.1126/science.1967194. PMID 1967194.
• S.J. Morrison, A.C. Spradling: Stem cells and niches: mechanisms that promote stem cell maintenance throughout life Cell, 132 (2008), pp. 598–611
• Ciliary biology: understanding the cellular and genetic basis of human ciliopathies. Cardenas-Rodriguez M, Badano JL. Am J Med Genet C Semin Med Genet. 2009 Nov 15; 151C(4):263-80
•  Cui, Cheng ; Chatterjee, Bishwanath ; Francis, Deanne ; Yu, Qing ; SanAgustin, Jovenal T. ; Francis, Richard ; Tansey, Terry ; Henry, Charisse ; Wang, Baolin ; Lemley, Bethan ; Pazour, Gregory J. ; Lo, Cecilia W. (2011).Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome. Dis Model Mech 4 (1): 43–56. doi:10.1242/dmm.006262. PMC 3008963.PMID 21045211.Jump up

Images Cited:

• centriole. Art. Britannica Online for Kids. Web. 1 Feb. 2015.  http://kids.britannica.com/comptons/art-5309
•  National Kidney and Urologic DiseasesInformation Clearinghouse (NKUDIC)." Polycystic Kidney Disease. Web. 2 Feb. 2015. .
• English: Conversion of a DICOM-format X-ray from a patient of en:User:Drgnu23, a ten year old male. This is the patient's left hand, posterior-anterior projection. Identifying tags and such have been stripped. The image is his, released under the GFDL. The image was subsequently altered by en:user:Grendelkhan, en:user: Raul654, and en:user:Solipsist., Own Work, http://commons.wikimedia.org/wiki/File:Polydactyly_01_Lhand_AP.jpg
• Wilking, Rick. "Obesity in America. Web. 2 Feb. 2015. http://blogs.reuters.com/photographers-blog/2012/05/22/obesity-in-america/.
• Word of Advice about Diabetes, Especially Juvenile Diabetes. | HowToCureDiabetes."HowToCureDiabetes. Web. 2 Feb. 2015. http://www.howtocurediabetes.org/.