Riboslam

Ribosomes

Ribosomes synthesize proteins in the cell. Pssh, unnecessary. To do this they translate the information in mRNA into peptide chains. They connect amino acid after amino acid. They tend to just hang on to the Rough ER or just float about in the cytoplasm like some lazy bums. I think we can all remember to that fateful night back in that cold winter some years back. Richard Ribosome, my competition, was at a formal party thrown by Governor Cell Wall and the poor guy didn't know his limits and lets just say he ended up spending the night with Chiraq's finest. Man, we never let him forget about this.

Do you really want this man to lead your country?

A mutation in small ribosomal subunits can lead to the disease known as Treacher Collins Syndrome which causes abnormalities in the facial features of the diseased. These individuals can have such abnormal ears and eyes that they can lose their hearing and vision, while it can be life threatening as well as it restricts air pathways. Thanks a lot ribosomes. Ribosomal malfunctions also lead to male infertility and Bowen Conradi Syndrome, just more negatives for this man who thinks he can be a leader. Male infertility is obvious why it is bad, but BCS is pretty severe. It is characterized by both prenatal and postnatal growth retardation, macrocephaly, a distinct facial appearance, extreme psychomotor delay, hip and knee contractures and rockerbottom feet. Those with it usually do not live past two years and if they do they have extreme growth failures. Very severe diseases thanks to ribosomes.

Treacher Collins Syndrome

Distinct Facial Features with BCS

Those were only mutations to small ribosomal subunits but there is disease and dysfunctions with mutations to the larger subunits. Two of these diseases are Alopecia, neurological defects, and endocrinopathy syndrome and Shwachman-Diamond Syndrome. ANE is characterized with hair loss, mental retardation, progressive loss of motor abilities, hypogonadism, short stature and macrocephaly. SDS is characterized with exocrine pancreatic insufficiency, bone marrow dysfunction, skeletal abnormalities and short stature. These two diseases brought on by ribosomal malfunctions is too severe to just tolerate. We cannot have an organelle with this much risk in charge.
 

Shwachman-Diamond Syndrome

Do we really want to have an organelle with this much opportunity to do bad be in charge? Chloroplasts do not harm anyone, we are the ultimate organelle and without them Lawrence and Peter could not have discussed what they would do with a million dollars. Thank you chloroplast, not you ribosomes, you could have hurt Lawrence.

More on the mugshot above. At Cell Wall's party, Ribosome was bragging about some Diamond he had recently created talking about how he was messing with people's bone marrow and skeleton after they purchased his diamond. It was even said that he somehow was causing people to become shorter and making it difficult for them to digest fats. He was mouthing this all off to the wrong guy, he was telling Officer Milton about his scheme and was arrested and sent to Vacuole County for the night. Richard has been put on many black lists due to this arrest and his scheme which is still around today as it is lingering and affecting many people worldwide.

Works Cited:

• Dauwerse JG, Dixon J, Seland S, Ruivenkamp CA, van Haeringen A, Hoefsloot LH, Peters DJ, Boers AC, Daumer-Haas C, Maiwald R, Zweier C, Kerr B, Cobo AM, Toral JF, Hoogeboom AJ, Lohmann DR, Hehr U, Dixon MJ, Breuning MH, Wieczorek D. Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome. Nat Genet. 2011 Jan;43(1):20-2. doi: 10.1038/ng.724. Epub 2010 Dec 5. PubMed citation
• Benne R, Sloof P (1987). "Evolution of the mitochondrial protein synthetic machinery".BioSystems 21 (1): 51–68. doi:10.1016/0303-2647(87)90006-2. PMID 2446672.
• James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
• Dror Y, Donadieu J, Koglmeier J, Dodge J, Toiviainen-Salo S, Makitie O, Kerr E, Zeidler C, Shimamura A, Shah N, Cipolli M, Kuijpers T, Durie P, Rommens J, Siderius L, Liu JM. Draft consensus guidelines for diagnosis and treatment of Shwachman-Diamond syndrome. Ann N Y Acad Sci. 2011 Dec;1242:40-55. doi: 10.1111/j.1749-6632.2011.06349.x. PubMed citation
• Result Filters.National Center for Biotechnology Information. U.S. National Library of Medicine. Web. 2 Feb. 2015. http://www.ncbi.nlm.nih.gov/pubmed/18439547.

Images Cited:

• Choroby Rzadkie: Zespół Treacher-Collins'a. Choroby Rzadkie: Zespół Treacher-Collins'a. Web. 2 Feb. 2015. http://chorobyrzadkie.blogspot.com/2012/09/zespo-treacher-collinsa.html.
• OMIM Clinical Synopsis - 1170 - ACROFACIAL DYSOSTOSIS SYNDROME OF RODRIGUEZ. OMIM Clinical Synopsis - 1170 - ACROFACIAL DYSOSTOSIS SYNDROME OF RODRIGUEZ. Web. 2 Feb. 2015. http://www.omim.org/clinicalSynopsis/201170
• CDD Congenital Diarreheal Disorders - Prof. Roberto Berni Canani. CDD Congenital Diarreheal Disorders - Prof. Roberto Berni Canani. Web. 2 Feb. 2015. http://www.congenitaldiarrhealdisorders.net/defects_digestion/testo_03_i.aspx.